Juan José Gómez-Piña, Hospital de especialidades “Dr. Antonio Fraga Mouret”, Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, CDMX, Mexico
Amairani Sierra Hernandez, Hospital de especialidades “Dr. Antonio Fraga Mouret”, Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, CDMX, Mexico


Introduction: Stroke is one of the main causes of disability in elderly, and the main cause of neurological emergencies. Mean platelet volume (MPV) has a positive correlation with prothrombotic diseases, highlighting thrombotic events and venous thrombosis disease. Aim: We aim to determine the relation between neutrophil/lymphocyte (N/L) index and MPV/platelet count (PC) index with prognosis in cerebral vascular events in the Mexican population. Methods: We included 236 patients with 137 males (74-78 years) and 81 females (64-72 years); 58 hemorrhagic cases, 44 parenchymal, eight subarachnoid, and 6 subdural; 160 ischemic cases, including 149 ischemic, 2 lacunar, and 9 Transient Ischemic Attack (TIA). All patients had brain imaging, initial, and follow-up hematic cytometry to determine indexes and compare it between them. Results: Neutrophils/lymphocytes index lower than 3 (p = 0.015) and MPV/PC index higher than 0.031 (p = 0.001) increase significantly in stroke during the first 48 h. MPV > 10 fl increase mortality (p = 0.014); considering all strokes; receiver operating characteristic curve showed AUC values of MPV/PC 0.822 (0.760-0.885) (p = 0.001) and N/L 0.661 (0.579-0.742) (p = 0.001) with a significant difference between AUC values (p = 0.001). Conclusions: In our study, mortality rises in patients over 70 years old, especially in hemorrhagic events, females; and patients with higher N/L and MPV/PC indexes. The MPV/ PC is better at predicting severity and long hospital stay in stroke compared to the N/L index. The high platelets levels are related to stroke as well as other studies before; however, this is related to the worst prognosis, increasing mortality and long hospital stay in our population.



Keywords: Mean platelet volume. Neutrophils lymphocytes ratio. Neutrophils/lymphocytes. Stroke. Mortality.