José L. Góngora-Alfaro, Autonomous University of Yucatan, Department of Neurosciences, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Mérida, Yucatan, Mexico
Manuel J. Gurubel-Maldonado, Autonomous University of Yucatan, Department of Neurosciences, Centro de Investigaciones Regionales Dr. Hideyo Noguch, Mérida, Yucatan, Mexico
Luis E. Parra Medina, Autonomous University of Yucatan, Department of Neurosciences, Centro de Investigaciones Regionales Dr. Hideyo Noguchi; Mérida, Yucatan, Mexico
Eddgar García-Santamaría, Physiological Science Department. School of Medicine, Autonomous University of Yucatán, Yucatán, Mexico
Roberto Leal-Ortega, Neurology Service at: Hospital Faro del Mayab, Mérida, Yucatan, Mexico
Jorge E. Salazar-Ceballos, Neurology Service at: Hospital Regional del ISSSTE Elvia Carrillo Puerto. Mérida, Yucatan, Mexico
Gloria Arankowsky-Sandoval, Autonomous University of Yucatan, Department of Neurosciences, Centro de Investigaciones Regionales Dr. Hideyo Noguch, Mérida, Yucatan, Mexico


Objective: The objective of the study is to identify the risk and protective factors associated with Parkinson’s disease (PD) in inhabitants of Yucatan. Methods: Case control study. A questionnaire with the main risk and protective factors for PD described in the literature was applied to cases and controls. Results: The sample consisted of 85 cases and 124 controls. In the univariate logistic regression analyzes, it was found that the following factors were significantly associated with a higher risk of developing PD: family history of PD (OR = 5.28, p = 0.001), personal history of diabetes (OR = 2.35, p = 0.01), the number of head trauma (OR = 1.35, p = 0.02), number of general anesthesia received (OR = 1.27, p = 0.050), exposure to organic solvents (OR = 2.73, p = 0.02) and the years of exposure to organic solvents (OR = 1.05, p = 0.01): Conclusions: The findings of this research indicate that the inhabitants of the state of Yucatan are exposed to the following risk factors: having a relative with PD, personal history of diabetes, number of head traumas, exposure to organic solvents, years of exposure to organic solvents and number of general anesthesia received.



Keywords: Case-control study. Parkinson’s disease. Risk and protection factors. Head trauma. General anesthesia.